November 8, 2017
November 8, 2017 —
Chronic inflammation is known to drive many cancers, especially liver cancer. Researchers have long thought that’s because inflammation directly affects cancer cells, stimulating their division and protecting them from cell death. But University of California San Diego School of Medicine researchers have now found that chronic liver inflammation also promotes cancer by suppressing immunosurveillance — a natural defense mechanism in which it’s thought the immune system suppresses cancer development.
November 1, 2017
November 1, 2017 —
In the Earth Microbiome Project, an extensive global team co-led by researchers at University of California San Diego, Pacific Northwest National Laboratory, University of Chicago and Argonne National Laboratory collected more than 27,000 samples from numerous, diverse environments around the globe. They analyzed the unique collections of microbes — the microbiomes — living in each sample to generate the first reference database of bacteria colonizing the planet. Thanks to newly standardized protocols, original analytical methods and open data-sharing, the project will continue to grow and improve as new data are added.
October 10, 2017
October 10, 2017 —
Approximately 10 percent of Americans take a proton pump inhibitor drug to relieve symptoms of frequent heartburn and acid reflux. That percentage can be much higher for people with chronic liver disease. Researchers at University of California San Diego School of Medicine have discovered evidence in mice and humans that these medications alter gut bacteria in a way that promotes three types of chronic liver disease. The study is published October 10 in Nature Communications.
September 29, 2017
September 29, 2017 —
Researchers at University of California San Diego School of Medicine have developed the first mice that lack the Upf3b gene, providing a new model for studying its underlying role in intellectual disabilities and neurodevelopmental disorders.
September 27, 2017
September 27, 2017 —
Cancers driven by mutations in the KRAS gene are among the most deadly. For decades, researchers have tried unsuccessfully to directly target mutant KRAS proteins as a means to treat tumors. Instead of targeting mutant KRAS itself, researchers at University of California San Diego School of Medicine are now looking for other genes or molecules that, when inhibited, kill cancer cells only when KRAS is also mutated.
September 11, 2017
September 11, 2017 —
Researchers at University of California San Diego School of Medicine and collaborators discovered a new kind of glycan (sugar chain) that survives even in a 4 million-year-old animal fossil from Kenya, under conditions where ancient DNA does not. While ancient hominin fossils are not yet available for glycan analysis, this proof-of-concept study, published September 11 in Proceedings of the National Academy of Sciences, sets the stage for unprecedented explorations of human origins and diet.
September 6, 2017
September 6, 2017 —
The Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego now offers a Master of Science in Drug Development and Product Management. This is the pharmacy school’s first master’s degree program. The program is intended for experienced professionals to gain managerial and regulatory knowledge required to lead all aspects of the drug development process, from discovery to clinical application in managed markets.
August 28, 2017
August 28, 2017 —
In mouse experiments, researchers at University of California San Diego School of Medicine have discovered that drugs that activate the cells’ proteasome, or recycling center, tip the balance in favor of memory CD8+ T cells. This approach could be used to improve how well vaccines and immunotherapies work and how long they last.
August 23, 2017
August 23, 2017 —
The public's help is being enlisted in the Microbiome Immunity Project, what's thought to be the biggest study to date of the human microbiome — the communities of bacteria and other microbes that live in and on the human body, where they influence our health.
August 23, 2017
August 23, 2017 —
The public's help is being enlisted in the Microbiome Immunity Project, what's thought to be the biggest study to date of the human microbiome — the communities of bacteria and other microbes that live in and on the human body, where they influence our health.
